Biological Responses to Low Dose Radiation-Hormesis and Adaptive Responses-
نویسندگان
چکیده
منابع مشابه
Low-dose radiation: thresholds, bystander effects, and adaptive responses.
I onizing radiation fills the universe. Daily ionizing particles and rays collide with molecules in 1% of the 100 trillion cells that make up the average human. These collisions generate clusters of free radicals known as reactive oxygen species that randomly damage cellular constituents including DNA (1). Certain types of ionizing radiation are more effective at generating reactive oxygen spec...
متن کاملBiologic responses to low doses of ionizing radiation: Detriment versus hormesis. Part 2. Dose responses of organisms.
The damage and signaling to cells and tissues with subsequent stimulatory responses induced by low doses of ionizing radiation were reviewed in Part 1 (J Nucl Med. 2001;42[7]:17N–27N). In the intact organism, these responses are expressions of complex adaptive systems that maintain homeostatic control essential for survival. The antimutagenic DNA damage-control system is the central component o...
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The term hormesis describes a dose-response relationship that is characterized by a response that is opposite above and below the toxicological or pharmacological threshold. Previous reports have shown that this relationship is ubiquitous in the response of pharmaceuticals, metals, organic chemicals, radiation, and physical stressor agents. Recent reports have also indicated that certain nanopa...
متن کاملMechanisms and biological importance of photon-induced bystander responses: do they have an impact on low-dose radiation responses
Elucidating the biological effect of low linear energy transfer (LET), low-dose and/or low-dose-rate ionizing radiation is essential in ensuring radiation safety. Over the past two decades, non-targeted effects, which are not only a direct consequence of radiation-induced initial lesions produced in cellular DNA but also of intra- and inter-cellular communications involving both targeted and no...
متن کاملLow-dose radiation induces antitumor effects and erythrocyte system hormesis.
OBJECTIVE Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. METHODS Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the r...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 2006
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi.126.827